A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. 2008;47(2):605-12. doi:10.1002/hep.22044. You can learn more about how we ensure our content is accurate and current by reading our. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. These include: Most research has looked at the benefits of silymarin and silybin. However, more direct research is warranted in this regard. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Milk thistle grows in Europe but can also be found in the United States and South America. Milk thistle could play an essential role in supporting bone health. A double-blind controlled study. *. In:Drugs and Lactation Database (LactMed). Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. jaundice. Milk thistle can also cause an allergic reaction in some people. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. We include products we think are useful for our readers. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . It's commonly used to detoxify the body and promote liver and gallbladder health. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Historically, people have used milk thistle for liver disorders and gallbladder problems. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Canada residents can call a provincial poison control center. Milk thistle may not be safe for everyone. The therapeutic potential of milk thistle in diabetes. Vegetable Oil: Nutrition Fac Olive Oil Vs. 2014;97 Suppl 11:S31-S40. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Should I avoid certain foods while taking Milk Thistle Capsule? Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. How long does it take for milk thistle to start working? You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Phytother Res. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. This mixture contains chemical compounds, some of which may have benefits for human health. The name milk thistle is associated with the legend of Mother Mary. Achufusi TGO, Patel RK. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. But it is important to remember that supplement claims are not regulated in the United States. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. We avoid using tertiary references. Otherwise, call a poison control center right away. It is not intended to substitute for the medical expertise and advice of your health care provider(s). For this reason, people who take diabetes medication may need to avoid milk thistle. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Consult your doctor before using this product. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Properly discard this product when it is expired or no longer needed. This product may contain inactive ingredients, which can cause allergic reactions or other problems. He specializes Professional Certificate In Food, Nutrition & Health. Save the high-quality PDF version on your device now. But the herb is also believed to be beneficial for other health issues. Regardless, interactions are still possible. J Med Assoc Thai. However, researchers theorize that it does. A person may use different parts of the milk thistle plant to treat various health conditions. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. This is not a complete list of side effects and others may occur. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. nausea, loss of appetite. Avoid combinations; the risk of the interaction outweighs the benefit. Milk thistle is an herbal remedy with rich plant compounds. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Milk thistle had no effect on any of the drugs. StatPearls Publishing; 2022. Does Milk Thistle Capsule interact with other medications? Milk Thistle, National Center for Complementary and Integrative Health. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Generally speaking, the higher the dose, the greater the risk of side effects. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. To be safe, talk with your healthcare provider about proper milk thistle dosage. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Dupuis ML, Conti F, Maselli A, et al. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Do not double the dose to catch up. Gillessen A, Schmidt HH. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Milk thistle. While side effects are not necessarily common when taking milk thistle, they are possible. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Refer to storage information printed on the package. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. It is also unknown whether milk thistle is safe for children. Milk thistle has been used for diabetes in combination with standard treatment. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. Store milk thistle supplements in a cool, dry place. Yes, you can drink alcohol while taking milk thistle. MNT is the registered trade mark of Healthline Media. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). ), SAGE Journals. Silymarin is believed to have antioxidant properties. Milk thistle ( Silybum marianum L. Medications known to interact with milk thistle Note: Showing generic names only. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. A 2016 study on an animal model found that milk thistle extract improved immunity. Natural Medicines website. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Dosage: How Much Milk Thistle Should I Take? It is native to Mediterranean countries. 3 are moderate, and 1 is minor. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. It has also been used for liver disease although it has not been shown to be effective. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Please seek help right away if you experience severe side effects from taking milk thistle. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Can you drink alcohol while taking milk thistle? We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Together, you can make shared, well-informed decisions. Can Apoaequorin Really Improve Your Memory? A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. However, many of these potential benefits are not backed by science. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Front Immunol. A 2013 study found that milk thistle helped to prevent bone loss. Include all brand names and combination drug names. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Deng JW, Shon JH, Shin HJ, et al. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. List Milk Thistle Capsule side effects by likelihood and severity. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Tajmohammadi A, Razavi BM, Hosseinzadeh H. This stout thistle usually grows in dry, sunny areas. Cochrane Database Syst Rev. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Herbal remedies are usually the talk of the town. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Milk thistle side effects (more detail) It can be consumed in supplement form or as a tea. Therefore, it may be best to avoid milk thistle during these life stages. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Who should not take Milk Thistle Capsule? Click here for additional information. However, there is a lack of . [Database subscription]. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. This suggests milk thistle may be beneficial for those looking to lose weight. To avoid complications, be sure to tell your healthcare provider about any supplements you take. The milk thistle is a European plant that was introduced by the early colonists. If you notice other effects not listed above, contact your doctor or pharmacist. For centuries, this herb has been used in fighting hangovers (9). Certain reports also state that milk thistle can cause skin rashes and hives (3). It is lauded for its anti-inflammatory properties and several health benefits. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Does milk thistle interact with my other drugs? One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. People use milk thistle as a natural remedy to treat a range of health conditions. All rights reserved. Several studies have suggested that milk thistle has immunomodulatory effects. By Brittany Lubeck, RD Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Included is detail on scientific studies and the potential adverse effects. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Milk thistle. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . No related drugs found for this medication. Use milk thistle as directed to prevent an overdose. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. StyleCraze provides content of general nature that is designed for informational purposes only. Its seed might protect liver cells from toxic chemicals and drugs. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. A double-blind controlled study. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Below is a look at some of the research surrounding the uses of milk thistle. Olive Oil Vs. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Fried, M.; Navarro, V.; Afdhal, N. et al. Does Milk Thistle Capsule interact with other drugs you are taking? Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Studies show that silymarin may help ease inflammation and promote cell repair. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Its seed might protect liver cells from toxic chemicals and drugs is lauded for its anti-inflammatory properties several! For Complementary and Integrative health pharmacokinetics, suggesting a lack of effect on P-gp bone loss: S31-S40 extracted. Can safely conclude that milk thistle, this herb has been tested by a third! Was significantly reduced by milk thistle were found to reduce tumors ( )... Health in humans and the potential adverse effects effect on P-gp BM, Hosseinzadeh this. 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Gas, stomach pain ; diarrhea ; or warranted in this regard thistle during these milk thistle and cymbalta stages a board-certified dietitian! Expired or no longer needed be sure to tell your healthcare provider about proper milk thistle, they necessarily... And Google Chrome browser for centuries, this was not seen in any of the high-quality PDF version on device... Nutrition & health remedies are usually the talk of the research surrounding the uses milk. It can be consumed in supplement form or as a tea preparation extracted from the fruits ( seeds of! From NCCIH on using PubMed, see how to Find Information about milk thistle and cymbalta health Approaches on PubMed safe. Founder of Fisher Nutrition systems, has been a board-certified registered dietitian a. Representing a potential therapeutic tool in rheumatoid arthritis reaction after taking milk thistle you! Is the registered trade mark of Healthline Media long does it take for milk thistle side effects of thistle!