For dogs with a history of seizures: consider carefully. this link is to an external site that may or may not meet accessibility guidelines. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. Apparently many pet owners lack the critical thinking skills it takes to fully reason this out. He is still not himself, walks very slowly and is definitely not feeling his best. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. We are now back to regular vet with bloodwork every two weeks and still on meds and diarrhea but not as bad. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. First time for this adverse reaction. I gave him this medication last Thursday. Could this be caused by the med? He had full wellness exam three ago and was in perfect shape. Very small sample - many deformities, stillborn. The following morning he had another small seizure. I feel like the simperica trio has somehow affected his Pituitary/Andrenal glands are maybe even acting as blockers to them. Additionally, many tick-borne diseases can affect humans as well as pets. She had multiple seizures and developed pericardial effusion and myocarditis. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. He loves the taste of Simparica Trio and it's like a treat for him. On Jan 4th for the first time. She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). Never any issues with bravecto so we'll return to that medication. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). On the first day he woke up and peed in my bedroom floor. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. It's 5:53pm and he's acting very lethargic. My dog died from it after one dose within 24 hours. I never missed a day. They want another blood draw in 3 weeks to see where she is. Stressing out now. Later in the fall I noticed some leg tremors when she squatted. PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS A week and a half from taking the drug, he is still on 3 meds, taking fluids and starting to gain strength and eat food and drink water in very small amounts. What are the side effects of simparica trio for dogs? He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. They think its a spinal disease thats causing a lot of his symptoms and sent him home with four meds, I need to keep him totally calm, no playing, running etc. Saving money sounds great, right? Our guy is having pain and is showing arthritic symptoms. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. I am sure simparica caused a fatal seizure in my boxer. My husband said that he felt like it would just make his coat shiny. I just started my 80 pound pit on this same medication yesterday. Conclusion I started crying carrying his body to my husband . Stopped meds and he has had 3 more seizures since. What scared me and caused me to start doing some more research is while drinking he stops and acts as if he has a lot of peanut butter in his mouth. He had to be put to sleep and Im devastated. I thought right away it must be the new meds! However, since the seizure a month ago he suddenly had another one when we tried to sleep in another bedroom while painting our bedroom ( where he slept with us). Today June 1,2022 she is still having neurological problems. Is it possible that Simparica could cause neurological issues with my dog. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. Hope your pup is doing better!! He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. Now his tail looks like a rat tail. Omg, this is beyond awful and makes me so worried. About 11 months ago our vet recommended Simparica Trio. I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Yea so what about the 10 percent? Meaning he is suppose to get it today. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. I keep praying she will recover and I feel so guilty for giving it to her. I have been telling everyone not to give this to their furry ones!!!!!!!! He developed these big sores which scab over quickly, hair falling out here and there. This can help with feelings of anxiety, stress, and fear." Hi, any chance you did a spinal tap? But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. If anyone has suggestions or knows how else I can help my little guy please let me know. I just wanted them gone and for him to feel better. He is like our baby because our son has left the nest and joined the US Navy. At first B seemed fine. I wish I would have seen this site before I gave it my Matty. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. The vet suggested Simparico trio . Both of them aren't eating like they were. He looked like he was having a seizure. Gave this to my 8 week old puppy yesterday, he was fine, but today he is very irritated and acting aggressive which he wasnt before. Tuesday morning she woke up with horrible diarrhea. Im switching back to the old stuff. These include vomiting, diarrhea, lethargy, inappetence, itching, and, very . Sarolaner is also used in combination products for both dogs and cats. I hope it has no permanent impact on him. Poor baby has had vomiting and diarrhoea ever since. She seems to be feeling better but still very concerned of why these levels are still up. The FDA continues to monitor adverse drug event reports for these products and encourages pet owners and veterinarians to report adverse drug events. He has horrible water like stools. She still has her appetite at the moment. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. I'll be calling them tomorrow. I am trying to remain confident that my poor girl will recover. The flavored, chewable tablets were consumed . My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. He said it would take care of ticks and Trifexis doesn't. My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. I just cross my fingers every day that she will get better after this is out of her system. Shes now in the Er. I'll be spreading the word. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. Somedays he will have 2 and then he will go for a couple days without having any issues. How is your cockapoo doing now? They recommended I hospitalize my dog immediately as it's a concern and he's currently there receiving IV fluids, meds, and after an ultrasound is now receiving medication for possible liver infection. not eating alor and wants me to rub her tummy constantly . Two days later, she is doing better, but not 100% yet. My American Akita puppy took this pill on August 8th. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. Last month she had diarrhea and it lasted 7 days. If she had just taken it they could give her Charcoal. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. . Its been 3 months and she continues to have them. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. Two months no flare up no more scabs and loosing hair. I PRAY that our baby is okay with this second dose. He had an MRI and it came out good. Never had them ever and she's only 3 1/2 yrs old. I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. He has all the symptoms Eveyone is describing. I cant believe how long this thread is. Sunday, he was lethargic and refused to eat. Has anyone experienced cardiac issues while under anesthesia on this medication? The only thing we changed after his checkup if Feb. was his flea and tick treatment. The exact same thing is happening to my dog now. Im beside myself with guilt and fear. He is very friendly with other people and pets and never had an issue in that regard. I read all the above and it makes me sad. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Thank you all so much!!!! Simparica only offers chewables. Does any one think this could be a reaction to Simparico Trio? As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. This is so awful. They are both potty trained, but one keeps using the bathroom in the house. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. It is Easter Sunday and he still has diarrhea and drinking a crazy amount of water. He has been low energy since. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. He scratched at them which made it worse. Lost his appetite & was low on energy all day yesterday, slept most of the day - which is very unusual for him. Doesn't anyone here wonder why?, if this is sooo safe to use with mammals, isn't there a human version also available? These dog training tips will help you get started. Hes not well..we hope he recovers fully! Did you ever get to the bottom of redness in eyes? Then the following week 1 pill every other day . This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. Simparica Trio covers the most common dog parasites and typically costs less than buying separate products. Side effects with Simparica are not common. Simparica Trio has been extensively tested on various breeds and on dogs of different ages. Shame on you! It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. I know Dukes problems were from this medicine, and it upsets me that my vet told me that this medicine was safe! 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. I'm so upset. Our 6 year old, 66# Treeing Walker Coon Hound baby has been taking Simparica for about two years. My Labradoodle had extreme diarrhea last night. Vet trip and meds $400! I wish I would have read these comments first. How did your baby do please? Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). I gave my 5m old pup this drug - she collapsed in the evening and was unable to walk. For 5 years I have resisted my veterinarians suggestions for oral flea meds. 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